大分大学　医学部
病態生理学講座
助教

高成　広起

専門分野

心臓電気生理、不整脈

所属部署

病態生理学講座（公式HP）

業績

ORIGINAL ARTICLES

1. Okuda T, Takanari H, Shiotani S, Hayakawa H, Ohno Y, Fowler DR: Pericardial tear as a consequence of cardiopulmonary resuscitation (CPR) involving chest compression: A report of two postmortem cases of acute type A aortic dissection with hemopericardium. Legal Med 2015;17:201-4（査読あり）

2. Takanari H, Nalos L, Stary-Weinzinger A, de Git KCG, Varkevisser R, Linder T, Houtman MJC, Peschar M, de Boer TP, Tidwell RR, Rook MB, Vos MA, van der Heyden MAG: Efficient and specific cardiac I_K1 inhibition by a new pentamidine analogue. Cardiovasc Res 2013;99:203-14（査読あり）

3. Verkevisser R, Houtman MJ, Waasdorp M, Man JC, Heukers R, Takanari H, Tieland RG, van Bergen En Henegouwen PM, Vos MA, van der Heyden MA: Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine. Eur J Physiol 2013;465:247-59（査読あり）

4. Takemoto Y, Takanari H, Honjo H, Ueda N, Okuno Y, Harada M, Kato S, Yamazaki M, Sakuma I, Opthof T, Kodama I, Kamiya K: Inhibition of intercellular coupling stabilizes spiral-wave reentry, whereas enhancement of the coupling facilitates unpinning and early termination of the reentry. Am J Physiol Heart Circ Pysiol 2012;303:H578-86（査読あり）

5. Harakalova M, van Harssel JJ, Terhal PA, van Lieshout S, Duran K, Renkens I, Amor DJ, Wilson LC, Kirk EP, Turner CL, Shears D, Garcia-Minaur S, Lees MM, Ross A, Venselaar H, Vriend G, Takanari H, Rook MB, van der Heyden MA, Asselbergs FW, Breue HM, Swinkels ME, Scurr IJ, Smithson SF, Knoers NV, van der Smagt JJ, Nijman IJ, Kloosterman WP, van Haelst MM, van Haaften G, Cuppen E: Dominant missense mutation in ABCC9 cause Cantu syndrome. Nat Genet 2012;44:793-6（査読あり）

6. Kato S, Honjo H, Takemoto Y, Takanari H, Suzuki T, Okuno Y, Opthof T, Sakuma I, Inada S, Nakazawa K, Ashihara T, Kodama I, Kamiya K: Pharmacological blockade of I_Ks destabilizes spiral-wave reentry under β-adrenergic stimulation in favor of its early termination. J Pharmacol Sci 2012;119:52-63（査読あり）

7. Houtman MJC, Takanari H, Kok BGJM, van Eck M, Montagne DR, Vos MA, de Boer Tp, van der Heyden MAC. Experimental mapping of the canine KCNJ2 and KCNJ12 gene structures and functional analysis of canine Kir2.2 ion channel. Frontiers Physiol 2012;3:9（査読あり）

8. Muramatsu T, Matsushita K, Murohara T: NAGOYA HEART Study Investigators: Comparison between valsartan and amlodipine regarding cardiovascular morbidity and mortality in hypertensive patients with glucose intolerance: NAGOYA HEART Study. Hypertension 2012; 59(3): 580-6（査読あり）

9. Yoshida M, Okusa T, Nakashima T, Takanari H, Yano M, Takemura G, Honjo H, Kodama I, Mizukami Y, Matsuzaki M: Alterations in adhesion junction precede gap junction remodeling during the development of heart failure in cardiomyopathic hamster. Cardiovasc Res 2011;92:95-105（査読あり）

10. Takanari H, Honjo H, Takemoto Y, Suzuki T, Kato S, Harada M, Okuno Y, Ashihara T, Opthof T, Sakuma I, Kamiya K, Kodama I: Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling. J Pharmacol Sci 2011;115:15-26（査読あり）

11. Harada M, Tsuji Y, Ishiguro YS, Takanari H, Okuno Y, Inden Y, Honjo H, Lee JK, Murohara T, Sakuma I, Kamiya K, Kodama I: Rate-dependent shortening of action potential duration increases ventricular vulnerability in failing rabbit heart. Am J Physiol Heart Circ Physiol 2011;300:H565-73（査読あり）

12. Nakagawa H, Honjo H, Ishiguro YS, Yamazaki M, Okuno Y, Harada M, Takanari H, Sakuma I, Kamiya K, Kodama I: Acute amiodarone promotes drift and early termination of spiral wave re-entry. Heart and Vessels 2010;25:338-47（査読あり）

13. Ishiguro YS, Honjo H, Opthof T, Okuno Y, Nakagawa H, Yamazaki M, Harada M, Takanari H, Suzuki T, Morishima M, Sakuma I, Kamiya K, Kodama I: Early termination of spiral wave reentry by combined blockade of Na⁺ and L-type Ca²⁺ currents in a perfused two-dimensional epicardial layer of rabbit ventricular myocardium. Heart Rhythm 2009;6:684-92（査読あり）

14. Takanari H, Iwata T, Yamada K, Sawada K: A case report of Late stent malapposition in Cypher stents one year after stent implantation (In Japanese). Jpn J Interv Cardiol 2006; 21: 539-42（査読あり）

15. Asai N, Iwashita T, Murakami H, Takanari H, Ohmori K, Ichihara M, Takahashi M: Mechanism of Ret activation by a mutation at aspartic acid 631 identified in sporadic pheochromocytoma. Biochem Biophys Res Commun 1999; 255(3): 587-90（査読あり）

CHAPTERS & REVIEW ARTICLES

1. Kodama I, Honjo H, Yamazaki M, Harada M, Ishiguro YS, Takanari H, Kamiya K. Pharmacological modification of spiral wave reentry in ventricle: Feasibility and limitation of potassium channel blocker (In Japanese). Shindenzu. 2007; 27(4): 275-86. Review Article.